Truth is your alive to this day to share. I have dabbled with exogenous dht for about 10-12 weeks and have noticed a few things… gonna take a long cycle off seeing the symptoms of both things you mentioned I was experiencing symptoms as well.
I’m going to miss the way women smell when they’re ovulating, I appreciate your research and efforts breaking ground in this field.
No enanthate for me but honestly looking back at my experience on it… no man should be living that powerfully for an extended period of time, mental cognition on 10, sharpness of thinking and neuroticism at a all time low, crazy sex, the list goes on, I can go on for days about how enjoyable it was but I think discretion needs to be used with something so raw/powerful
I formulated it into a supplement called B4 that RampHealth.co sells
it utilizes MULTIPLE pathways to boost dopamine and GABA in ways an OTC supplement has never done before
This formula stretches the limits of what's possible with dietary supplements, here's how:
Oroxylin A: Dopamine reuptake inhibitor. Other examples of dopamine reuptake inhibitors include ritalin and cocaine.
Eria Jarensis: stimulates dopamine & norepinephrine release and inhibits reuptake
Agmatine Sulfate: studied for powerful antidepressant properties, NDMA receptor antagonist (examples include ketamine & memantine), increases dopamine release in striatum, a key brain region involved in motor control, reward, and mood regulation, and nhibits nitric oxide synthase in the brain.
L-Theanine: Competes with glutamate at NDMA receptors, blocking excitatory signaling and enhancing inhibitory signaling by making more glutamate available for GABA conversion
Lemon Balm Extract: increases GABA by inhibiting 4-aminobutyrate transaminase
Emoxypine: powerful stress reliever due to anti-oxidant, actoprotector, and GABA_A positive allosteric modulation properties.
Hmm I tried the original version which didn’t do much for me 🤷♂️ maybe I’ll give the new version a try.. For social settings I respond very well to Kanna and saffron to a lesser extent. Perhaps that means I’m better off with seratongenic supps? But from reading you and mgpapi I understand that topic is very nuanced
Interesting! Well you asked me what MY stack would be haha, would need a lot more info to suggest something for you. Yeah, sounds like you could have a serotonin imbalance in that case.
The new B4 is less sedating and more stimulating. Perhaps combine it with ND's kanna extract + saffron + maybe a low dose of 5HTP like 100mgs, nothing crazy. I find that more serotonin pairs well with higher dopamine, which B$ provides. Might be the case that you don't need the dopamine boost though, so experiment.
You have to make sure you eat 200g protein daily without excuses and other than that you just need a caloric deficit. Try eating around 2200 calories. Walk 10,000-15,000 steps for your health and to burn a few extra calories. Do some cardio on a bike maybe since it'll bee easier on your joints than say something like running. By the time you get to 12% bodyfat, insulin resistance won't be an issue. Ketogenic diet is probably a good idea in this situation too
Sorry to hear about the shoulder. Hope you recover well. Going into my senior year of college. I've really prioritized health in my first three years, but I'm moving into a house of 11 guys and people want me to ease up on alcohol avoidance and circadian adherence. If you were in my position and had to put back 4-5 drinks every other weekend, how would you do it? i.e. any supplements/foods you would take before, during, and after, and behaviors you would incorporate before, during, after (for ex. sauna, cardio, etc.)? Thanks in advance
Lol you're probably good! I created B4 by ramp health for this reason, it's actually alcohol defense (reduces neurotoxicity, increases metabolism) and great for needing less or none at all.
Other than that, usually an an extra gram or two of sodium that day, extra 8oz water for every unit of alcohol, some Mag Acetyl Taurate, NAC & DHM before and after, and some TUDCA the next day. I also make sure that If I'm gonna consume say 1000 calories of alcohol, I must do additional walking or exercises to burn 1000 more calories. I don't think eating less food is the answer if you care about muscles/nutritient status.
Well you want to get an 1:3 to 1:1 Omega3:Omega6 ratio, and it's very possible that a l ittle salmon every day isn't anywhere near cutting it, so yeah there's benefits for cognition, inflammation, cardiovascular health, etc
I am on 100 mg testosterone cypionate 2x / week. My doctor did prescribe HCG but I decided not to take it at least at the beginning. I just started taking 25 mg of DHEA in the morning and 50 mg of Pregnenolone in the evening and am seeing good results from it. Do people also take HCG on top of the DHEA and Pregnenolone or is it usually just one or the other?
Little late for asking my question to the thread, but I’ve seen you mention a lot about mirror skin (topical ghk). Do you have a skincare routine that you would stack mirror skin with? If so what products are they?
Not really. I feel like with good nutrition, sunlight exposure, artificial bluelight minimization, stress management, exercise and hygeine, the skin takes care of itself
Although I'm getting plenty anecdotes that BPC is also improving skin appearance and youthfulness
Bowtied Fawn is the go-to resource on skincare, so check her out
Started going to the gym and fucked my metabolism/insulin sensitivity because I was eating like an idiot to gain weight. Stopped for 2 years after I gained the weight I wanted and then got super insulin resistant and saw no more gains. Metabolism isn't the same as it used to be(maintained single digit body fat low carb high protein high fat diet. Just how I liked to eat wasn't a calcualted choice). I want to get back into the gym (I'm 60-62kg, 5'10, 12-13% bf) and have been going through all your posts. This is the conclusion I have come to from reading your posts:
3 day fast + deplete glycogen stores
cut to single digit bf with keto (what defecit / do I calculate maintenace as sedentary?)
strength based training with 4-6 reps and longer rest.
macros 1-1.5g protein/lb + fill the rest of calories with fat (do I even need any carbs?)
Once I hit desired body fat I should refeed carbs (how do you suggest I do this?) and then start eating as outlined in your post: https://x.com/BowTiedUM/status/1748833404500562176 and switch to a "hypertrophy" ppl program?
What would you do if you were in a similar situation?
Not asking for medical advice but if you had to devise a protocol with good risk profile supps/peptides (bpc-157, tongkat ali, nad+, maybe mk677, methylene blue, etc...) and you were too much of a pussy to take things with steroid/sarm like "studied" side effects what would it look like and what would the dosages/cycles look like.
Sorry for writing my life's story. I know it's rather long.
Hey. Recently been diagnosed with Trigeminal Neuropathy. Been prescribed Pea 600mg Twice a day. Currently been on it for nearly 7 weeks. I also have Psoriatic Arthritis which this supplement is helping but not getting any results for the facial/head/neck nerve pain.
Next line of medication is Nortriptyline among others. Any recommendations for nerve pain/damage?
Meant to ask has your adrenal gland recovered or are you on some sort of protocol for that? Lastly don’t mean to double dip but may have this a part in your injury? Best regards in your recovery
24 ng/ml??? yeah that could. You gotta get the CBC look at hemoglobin, hematocrit, and RBC also look at TIBC and serum iron to know what's going on. In the case of iron deficiency, you can usually benefit from red meat maxxing & vitamin c supplementation with meals to increase absorption
Based on your Testosterone Guide, would high FSH (11.7 mIU/mL), high LH (8 mIU/mL) and low T (380 ng/dL) usually be a sign of a testicular issue? Been bouncing around PC docs to find a decent one but none of them seem concerned bc T is technically not out of range. All bloodwork done on my own
Thanks for the content, there’s a lot of junk out there but your stuff is 🔥
Just started the natural hair loss protocol. I've always been leery of oral fin/dut. so I just have been on 2.5mg oral minox daily for the past 9 months but I dont seem to be a strong responder on the scalp except my beard is even tougher now which I didnt need lol. Is oral minox even worth it and is there potential for positive interaction effects with this protocol?
Didn't you ask this already bro? Or did someone else ask the same question.
I personally don't like minox because it's a potassium channel activator and can potentially have serious heart related side effects. Too risky for me, but I'm not going to tell you what to do. That's between you and doctor.
yup sorry, I responded to your other comment on the original hair protocol post and forgot to delete this. That was my gut reaction too as after 9 months I didn't see any improvement and felt the latent risk wasn't worth it but just wanted to see if I might be missing anything. Thanks for your response.
Of course there are downsides, but when done properly under medical supervision it's very worth it IN MY OPINION.
Of course if done improperly (without medical supervision or bad doctor) can have all sorts of issues with mood, energy, cognition, blood pressure, adrenals, etc.
If you're forced to stop there's always stuff like enclomiphene you can take to restart your HPG axis faster and go back to normal natural production, so I'm not worried about it
If done right it should be health and quality of life enhancing
Preferred test Ester? Looking into trt more closely and seems like there is a ton of variations. (Or just a good article/video or study you know of to read on my own.)
Depends on how often one is willing to inject. Most guys can only manage once or twice per week. They need cypionate or enanthate at the very least, but undecanoate would be better.
What I noticed is longer ester, more water retention, less DHT conversion, more estradiol conversion
The opposite is true of shorter esters like propionate and acetate
I like prop and acetate the best because when pinned daily, it sort of mimicks the diurnal rhythm, maximizes DHT, and ends up being the easiest to manage e2 on, but you MUST pin daily
Not a question just excited for the upcoming DHT post 😃
I suffered through adrenal fatigue and acute adrenal crisis to find the truth 🥲
Truth is your alive to this day to share. I have dabbled with exogenous dht for about 10-12 weeks and have noticed a few things… gonna take a long cycle off seeing the symptoms of both things you mentioned I was experiencing symptoms as well.
I’m going to miss the way women smell when they’re ovulating, I appreciate your research and efforts breaking ground in this field.
Looking forward to the post as well
They're gonna miss the way you smell when they're ovulating more HAHAHA
Did you use enanthate?
No enanthate for me but honestly looking back at my experience on it… no man should be living that powerfully for an extended period of time, mental cognition on 10, sharpness of thinking and neuroticism at a all time low, crazy sex, the list goes on, I can go on for days about how enjoyable it was but I think discretion needs to be used with something so raw/powerful
Wait what the fuck. I wanna hear more.
It’s insane, I literally could note all the things I felt and it was a completely different way of living
Cue the adrenochrome scene from fear & loathing
Got a best man speech coming up in a couple months… curious what your public speaking stack would be
I formulated it into a supplement called B4 that RampHealth.co sells
it utilizes MULTIPLE pathways to boost dopamine and GABA in ways an OTC supplement has never done before
This formula stretches the limits of what's possible with dietary supplements, here's how:
Oroxylin A: Dopamine reuptake inhibitor. Other examples of dopamine reuptake inhibitors include ritalin and cocaine.
Eria Jarensis: stimulates dopamine & norepinephrine release and inhibits reuptake
Agmatine Sulfate: studied for powerful antidepressant properties, NDMA receptor antagonist (examples include ketamine & memantine), increases dopamine release in striatum, a key brain region involved in motor control, reward, and mood regulation, and nhibits nitric oxide synthase in the brain.
L-Theanine: Competes with glutamate at NDMA receptors, blocking excitatory signaling and enhancing inhibitory signaling by making more glutamate available for GABA conversion
Lemon Balm Extract: increases GABA by inhibiting 4-aminobutyrate transaminase
Emoxypine: powerful stress reliever due to anti-oxidant, actoprotector, and GABA_A positive allosteric modulation properties.
Hmm I tried the original version which didn’t do much for me 🤷♂️ maybe I’ll give the new version a try.. For social settings I respond very well to Kanna and saffron to a lesser extent. Perhaps that means I’m better off with seratongenic supps? But from reading you and mgpapi I understand that topic is very nuanced
Interesting! Well you asked me what MY stack would be haha, would need a lot more info to suggest something for you. Yeah, sounds like you could have a serotonin imbalance in that case.
The new B4 is less sedating and more stimulating. Perhaps combine it with ND's kanna extract + saffron + maybe a low dose of 5HTP like 100mgs, nothing crazy. I find that more serotonin pairs well with higher dopamine, which B$ provides. Might be the case that you don't need the dopamine boost though, so experiment.
102kg/179cm, around 32-36% body fat, insulin resistant
How to burn fat with insulin resistance?
Since classic gym strength training creates like 1 kg muscle and 2 kg fat
What’s the proper way?
You have to make sure you eat 200g protein daily without excuses and other than that you just need a caloric deficit. Try eating around 2200 calories. Walk 10,000-15,000 steps for your health and to burn a few extra calories. Do some cardio on a bike maybe since it'll bee easier on your joints than say something like running. By the time you get to 12% bodyfat, insulin resistance won't be an issue. Ketogenic diet is probably a good idea in this situation too
Sorry to hear about the shoulder. Hope you recover well. Going into my senior year of college. I've really prioritized health in my first three years, but I'm moving into a house of 11 guys and people want me to ease up on alcohol avoidance and circadian adherence. If you were in my position and had to put back 4-5 drinks every other weekend, how would you do it? i.e. any supplements/foods you would take before, during, and after, and behaviors you would incorporate before, during, after (for ex. sauna, cardio, etc.)? Thanks in advance
Lol you're probably good! I created B4 by ramp health for this reason, it's actually alcohol defense (reduces neurotoxicity, increases metabolism) and great for needing less or none at all.
Other than that, usually an an extra gram or two of sodium that day, extra 8oz water for every unit of alcohol, some Mag Acetyl Taurate, NAC & DHM before and after, and some TUDCA the next day. I also make sure that If I'm gonna consume say 1000 calories of alcohol, I must do additional walking or exercises to burn 1000 more calories. I don't think eating less food is the answer if you care about muscles/nutritient status.
Thank you!
Are there any additional benefits to taking EPA as a supplement alongside eating salmon daily, or overkill?
Thanks!
Well you want to get an 1:3 to 1:1 Omega3:Omega6 ratio, and it's very possible that a l ittle salmon every day isn't anywhere near cutting it, so yeah there's benefits for cognition, inflammation, cardiovascular health, etc
Thanks man, appreciate it
I am on 100 mg testosterone cypionate 2x / week. My doctor did prescribe HCG but I decided not to take it at least at the beginning. I just started taking 25 mg of DHEA in the morning and 50 mg of Pregnenolone in the evening and am seeing good results from it. Do people also take HCG on top of the DHEA and Pregnenolone or is it usually just one or the other?
Little late for asking my question to the thread, but I’ve seen you mention a lot about mirror skin (topical ghk). Do you have a skincare routine that you would stack mirror skin with? If so what products are they?
Not really. I feel like with good nutrition, sunlight exposure, artificial bluelight minimization, stress management, exercise and hygeine, the skin takes care of itself
Although I'm getting plenty anecdotes that BPC is also improving skin appearance and youthfulness
Bowtied Fawn is the go-to resource on skincare, so check her out
Hello!
Started going to the gym and fucked my metabolism/insulin sensitivity because I was eating like an idiot to gain weight. Stopped for 2 years after I gained the weight I wanted and then got super insulin resistant and saw no more gains. Metabolism isn't the same as it used to be(maintained single digit body fat low carb high protein high fat diet. Just how I liked to eat wasn't a calcualted choice). I want to get back into the gym (I'm 60-62kg, 5'10, 12-13% bf) and have been going through all your posts. This is the conclusion I have come to from reading your posts:
3 day fast + deplete glycogen stores
cut to single digit bf with keto (what defecit / do I calculate maintenace as sedentary?)
strength based training with 4-6 reps and longer rest.
macros 1-1.5g protein/lb + fill the rest of calories with fat (do I even need any carbs?)
Once I hit desired body fat I should refeed carbs (how do you suggest I do this?) and then start eating as outlined in your post: https://x.com/BowTiedUM/status/1748833404500562176 and switch to a "hypertrophy" ppl program?
What would you do if you were in a similar situation?
Not asking for medical advice but if you had to devise a protocol with good risk profile supps/peptides (bpc-157, tongkat ali, nad+, maybe mk677, methylene blue, etc...) and you were too much of a pussy to take things with steroid/sarm like "studied" side effects what would it look like and what would the dosages/cycles look like.
Sorry for writing my life's story. I know it's rather long.
Hey. Recently been diagnosed with Trigeminal Neuropathy. Been prescribed Pea 600mg Twice a day. Currently been on it for nearly 7 weeks. I also have Psoriatic Arthritis which this supplement is helping but not getting any results for the facial/head/neck nerve pain.
Next line of medication is Nortriptyline among others. Any recommendations for nerve pain/damage?
Thanks 👍🏻
Meant to ask has your adrenal gland recovered or are you on some sort of protocol for that? Lastly don’t mean to double dip but may have this a part in your injury? Best regards in your recovery
Does FERRITIN level of 24 indicate iron deficiency?..what protocol will benefit me in that case,?
24 ng/ml??? yeah that could. You gotta get the CBC look at hemoglobin, hematocrit, and RBC also look at TIBC and serum iron to know what's going on. In the case of iron deficiency, you can usually benefit from red meat maxxing & vitamin c supplementation with meals to increase absorption
Based on your Testosterone Guide, would high FSH (11.7 mIU/mL), high LH (8 mIU/mL) and low T (380 ng/dL) usually be a sign of a testicular issue? Been bouncing around PC docs to find a decent one but none of them seem concerned bc T is technically not out of range. All bloodwork done on my own
Thanks for the content, there’s a lot of junk out there but your stuff is 🔥
Correct! You may have some fertility challenges if kids are desired, but at least they're somewhat working.
Does FERRITIN level of 20 indicate iron deficiency??
Just started the natural hair loss protocol. I've always been leery of oral fin/dut. so I just have been on 2.5mg oral minox daily for the past 9 months but I dont seem to be a strong responder on the scalp except my beard is even tougher now which I didnt need lol. Is oral minox even worth it and is there potential for positive interaction effects with this protocol?
Didn't you ask this already bro? Or did someone else ask the same question.
I personally don't like minox because it's a potassium channel activator and can potentially have serious heart related side effects. Too risky for me, but I'm not going to tell you what to do. That's between you and doctor.
yup sorry, I responded to your other comment on the original hair protocol post and forgot to delete this. That was my gut reaction too as after 9 months I didn't see any improvement and felt the latent risk wasn't worth it but just wanted to see if I might be missing anything. Thanks for your response.
What do you see as the downsides of TRT (with DHT) when done properly with hCG etc?
Besides having to pay and pin for the rest of life if one wants the benefits?
(things like travel issues, what if forced to stop (really no downsides?), risks etc.)
Ty!
Of course there are downsides, but when done properly under medical supervision it's very worth it IN MY OPINION.
Of course if done improperly (without medical supervision or bad doctor) can have all sorts of issues with mood, energy, cognition, blood pressure, adrenals, etc.
If you're forced to stop there's always stuff like enclomiphene you can take to restart your HPG axis faster and go back to normal natural production, so I'm not worried about it
If done right it should be health and quality of life enhancing
Preferred test Ester? Looking into trt more closely and seems like there is a ton of variations. (Or just a good article/video or study you know of to read on my own.)
Depends on how often one is willing to inject. Most guys can only manage once or twice per week. They need cypionate or enanthate at the very least, but undecanoate would be better.
What I noticed is longer ester, more water retention, less DHT conversion, more estradiol conversion
The opposite is true of shorter esters like propionate and acetate
I like prop and acetate the best because when pinned daily, it sort of mimicks the diurnal rhythm, maximizes DHT, and ends up being the easiest to manage e2 on, but you MUST pin daily