(This is entirely hypothetical.) Imagine an 18-year-old male who, during his early teenage years, experienced anorexia and underwent treatment involving antipsychotic and other pharmaceutical medications—possibly inappropriately administered. Hypothetically, if this individual were still undergoing pubertal development, what general principles or approaches could he consider to optimize physical and neurological development at this stage? Suppose this hypothetical person is open to considering various pharmaceutical interventions and possesses a high tolerance for risk.
This imaginary person might want to get shredded first and then experiment with medically supervised exogenous androgens in an HRT+ context, namely testosterone, proviron, and DHT
Would topical DHT and injectable esterless DHT have the same long term aromatase inhibiting affects as estered DHT? My assumption is yes, to an extent, since DHT acts as a suicide inhibitor there won't be a rebound in estrogen when the fast acting esterless DHT is out of the system
DHT's AI properties are so minor, you can't use it as an AI. This is because as dose increases, so does its estrogenic metabolites. It is mostly a SERM. this is why high doses of DHT cause simultaneous low and high e2 symptoms. This is also why some doses of DHT can treat gyno, while other doses can cause it.
What is the efficacy of andractim for increasing DHT levels of already on TRT at 160 mg/week?
What is a starting level that's equally effective to get DHT levels like on injectable DHT (obviously have to compensate for the lower absorption via transdermal) and how best to increase absorption?
Just bought the fire dragon for hair protocol. Does 2-3 x per day for 2-5 minutes apply with this particular device? Also, would increasing that dosage be beneficial or might there be negative effects?
It depends how much sun you're getting, but for context: we use the inferno, which is a lot bigger, for 20m 2-3x a day for full body coverage (sides, front, and back) and no goggles to reap the brain/eye benefits
Looking at vendors for injectable ghk-cu. They all come in 50-100mg vials. Was curious how you would properly reconstitute to minimize PIP(heard it’s an issue), and to make dosing not ridiculous with like 5 unit draws. Would you need to separate into additional vials or is keeping it in the one vial fine. Thanks!
1) I don't have any hair loss. No family history of baldness. However, being in my 30s, any broscience for getting rid of grays, or is dye really the only effective option?
2) Some family history of prostate cancer. I take tadalafil daily for other reasons, but beyond that, any broscience recommendations for prostate health?
The hair loss protocol is actually known to reverse grey hairs too. The light and nutrition aspect is very important.
We only do 1 question per AMA bro, but yeah keeping estradiol in range with testosterone + DHT >1000ng/dl and no more than 10:1 ratio seems like the move as would good circadian living, nutrition, sunlight exposure, and nnEMF/artificial light mitigation
I read anecdotal evidence of Xanthoparmelia, Mondia Whitei, Fedogia Agrestis, Cnidium and Butea Superba resulting in reversing grays. Was a side effect of trying to increase libido. I can send you it.
Do you have anywhere you have given your thoughts/a rundown of LDN and it's applications? Saw Richard was trying it and seen grim and bowtiedbeardeddragon plus a couple of others mention it as well.
ULDN (~50 micrograms per day) seems to be great for upregulating mu opioid/dopamine receptors while LDN (few mg per day) seems more beneficial for chronic inflammation mitigation/immunomudulatory properties
hi i`m gonna post my q from previous ama which wasnt answered
i`m doing all nighters for a few months because of bullmarket. Job isnt stressful but i need to be awake up to 6-7 am every night/morning
Currently doing biphasic sleep 6 am up to 12:30 ( hard to sleep more than that) , and then 7pm -8;30pm
tried to increase lenght of 1st sleep with mgn acetyl taurate and magnolia bark on high dosages ( 2g+ / 600mg) but i only get to fall asleep faster not longer. I got blackout curtains,earplugs etc.
Nutrition and bloodwork is ok, daily light as much as i can get. How can i increase the lenght
of the sleep? Any tips in general for my case will be helpfull. thank y
Male 33 , 155 lbs 5'11 training for a few years 12-14% bodyfat
Stuck at this weight due to carnivore (all attempts to reintroduce bone broth rice give me fungal issues/dandruff/balanitis/reduced cognition after a while)
Biomarkers are great , feeling great.
Any suggestions how to improve physique from here on?
Hypothetical subject wants to gain some more muscle while staying carnivore but seems to be hard
Have 1612w EMR , Sauna , high level Cold plunge
Supplements are Creatine , high quality Fulvic Acid for trace minerals , Magmaxing , vit e + coq10 (100mg) Krill Oil , Cialis for banana protocol + Selmak/Semax 5/2 cycling for cognition. I have both oral and injectable BPC-157 at home but haven't used yet (don't find reason to)
You're too fat to gain muscle rn IMO. Get to a real 8-10% bodyfat, then in the spring introduce some rice and potatoes to your diet and BLOW TF up! Carnivore probably has your free T absolutely decimated btw
After receiving these results, I tried an elimination diet with more red meat to reduce inflammation, as some markers were concerning.
My Total T increased to 786, but my Free T% decreased further to 1.44%, so I doubt my T:DHT ratio improved (I didn't retest DHT).
I want to improve overall health a bit more before I start TRT. Plus I want to keep my fertility so it's probably easier to not hop on TRT for now.
Total T is not terrible, and I think I can improve it further. Given that, it could make sense for me to supplement only DHT (topical) (without T) to upregulate 5AR, even if just for a few months.
As the upregulation change would be permanent, I could get over 1000 (DHT and T).
What dose would make sense to avoid suppressing endogenous DHT production too much (so I could recover relatively well)?
Do you have any experience with a Sperti Vitamin D panel? I live in a northern climate, and currently try to red light a couple times a week. I try to get outside as much as possible but given the short days it can be hard some days to get much sunlight.
Always thought autoimmunity, since runs strong in maternal line.
TPO antibodies used to be elevated years ago (with normal thyroid hormone markers), Hashimotos, signs of joint stuff in the past, but no change in platelets/MPV since all of that has improved.
Maybe time to revisit a more in depth thyroid panel.
Thanks for the reply. I ask because I actually have very similar bloods to you (including the trending low platelets and high MPV), but I'm also 11 years younger than you.
It makes sense that platelet turnover rate is higher, so newly produced platelets are younger and therefore larger, hence the increase in MPV as platelets stay down. I haven't checked bone marrow, but haven't come to a better understanding thus far. Any hunch on your end? I've been noticing it for probably 10 years.
(This is entirely hypothetical.) Imagine an 18-year-old male who, during his early teenage years, experienced anorexia and underwent treatment involving antipsychotic and other pharmaceutical medications—possibly inappropriately administered. Hypothetically, if this individual were still undergoing pubertal development, what general principles or approaches could he consider to optimize physical and neurological development at this stage? Suppose this hypothetical person is open to considering various pharmaceutical interventions and possesses a high tolerance for risk.
This imaginary person might want to get shredded first and then experiment with medically supervised exogenous androgens in an HRT+ context, namely testosterone, proviron, and DHT
Would topical DHT and injectable esterless DHT have the same long term aromatase inhibiting affects as estered DHT? My assumption is yes, to an extent, since DHT acts as a suicide inhibitor there won't be a rebound in estrogen when the fast acting esterless DHT is out of the system
DHT's AI properties are so minor, you can't use it as an AI. This is because as dose increases, so does its estrogenic metabolites. It is mostly a SERM. this is why high doses of DHT cause simultaneous low and high e2 symptoms. This is also why some doses of DHT can treat gyno, while other doses can cause it.
What is the efficacy of andractim for increasing DHT levels of already on TRT at 160 mg/week?
What is a starting level that's equally effective to get DHT levels like on injectable DHT (obviously have to compensate for the lower absorption via transdermal) and how best to increase absorption?
It's not that great because hormone levels aren't going to be stable, it distributes into tissues differently, and a tube would last about 2 weeks
You can't say it's equally effective. it's about 25% as good as DHT esters
any specific specs to be aware of / seek out when buying incandescents online?
You just want to make sure they're bright enough (60w) to light the room properly
Thanks!
Just bought the fire dragon for hair protocol. Does 2-3 x per day for 2-5 minutes apply with this particular device? Also, would increasing that dosage be beneficial or might there be negative effects?
It depends how much sun you're getting, but for context: we use the inferno, which is a lot bigger, for 20m 2-3x a day for full body coverage (sides, front, and back) and no goggles to reap the brain/eye benefits
Looking at vendors for injectable ghk-cu. They all come in 50-100mg vials. Was curious how you would properly reconstitute to minimize PIP(heard it’s an issue), and to make dosing not ridiculous with like 5 unit draws. Would you need to separate into additional vials or is keeping it in the one vial fine. Thanks!
My Setup:
2cc BAC water
.33cc Insulin syringes
Disregard PIP because it's really not that bad
1) I don't have any hair loss. No family history of baldness. However, being in my 30s, any broscience for getting rid of grays, or is dye really the only effective option?
2) Some family history of prostate cancer. I take tadalafil daily for other reasons, but beyond that, any broscience recommendations for prostate health?
The hair loss protocol is actually known to reverse grey hairs too. The light and nutrition aspect is very important.
We only do 1 question per AMA bro, but yeah keeping estradiol in range with testosterone + DHT >1000ng/dl and no more than 10:1 ratio seems like the move as would good circadian living, nutrition, sunlight exposure, and nnEMF/artificial light mitigation
I read anecdotal evidence of Xanthoparmelia, Mondia Whitei, Fedogia Agrestis, Cnidium and Butea Superba resulting in reversing grays. Was a side effect of trying to increase libido. I can send you it.
Do you have anywhere you have given your thoughts/a rundown of LDN and it's applications? Saw Richard was trying it and seen grim and bowtiedbeardeddragon plus a couple of others mention it as well.
ULDN (~50 micrograms per day) seems to be great for upregulating mu opioid/dopamine receptors while LDN (few mg per day) seems more beneficial for chronic inflammation mitigation/immunomudulatory properties
How would you go about bio hacking hyper mobility?
hi i`m gonna post my q from previous ama which wasnt answered
i`m doing all nighters for a few months because of bullmarket. Job isnt stressful but i need to be awake up to 6-7 am every night/morning
Currently doing biphasic sleep 6 am up to 12:30 ( hard to sleep more than that) , and then 7pm -8;30pm
tried to increase lenght of 1st sleep with mgn acetyl taurate and magnolia bark on high dosages ( 2g+ / 600mg) but i only get to fall asleep faster not longer. I got blackout curtains,earplugs etc.
Nutrition and bloodwork is ok, daily light as much as i can get. How can i increase the lenght
of the sleep? Any tips in general for my case will be helpfull. thank y
Hypothetical scenario is :
Male 33 , 155 lbs 5'11 training for a few years 12-14% bodyfat
Stuck at this weight due to carnivore (all attempts to reintroduce bone broth rice give me fungal issues/dandruff/balanitis/reduced cognition after a while)
Biomarkers are great , feeling great.
Any suggestions how to improve physique from here on?
Hypothetical subject wants to gain some more muscle while staying carnivore but seems to be hard
Have 1612w EMR , Sauna , high level Cold plunge
Supplements are Creatine , high quality Fulvic Acid for trace minerals , Magmaxing , vit e + coq10 (100mg) Krill Oil , Cialis for banana protocol + Selmak/Semax 5/2 cycling for cognition. I have both oral and injectable BPC-157 at home but haven't used yet (don't find reason to)
never did hgh / trt but open to it
You're too fat to gain muscle rn IMO. Get to a real 8-10% bodyfat, then in the spring introduce some rice and potatoes to your diet and BLOW TF up! Carnivore probably has your free T absolutely decimated btw
What is a good starting dose for trizepatide?
We found 2.5mg to be more than enough
What have been the top 3 activities/lifestyle modifications you have made in the last 5 years. Judging based on ROI or return on time. Cheers.
-Sunrise/sunset walks daily
- Indoor light environment optimization
- Starting day off with a 75g+ protein meal
Total T: 619
Free T: 107
Free T %: 1.73
DHT: 26.7
T:DHT ratio: 23.2 (I want 8...)
E2: 21.6
Prolactin: 6.51
FSH: 5.1
LH: 4.4
After receiving these results, I tried an elimination diet with more red meat to reduce inflammation, as some markers were concerning.
My Total T increased to 786, but my Free T% decreased further to 1.44%, so I doubt my T:DHT ratio improved (I didn't retest DHT).
I want to improve overall health a bit more before I start TRT. Plus I want to keep my fertility so it's probably easier to not hop on TRT for now.
Total T is not terrible, and I think I can improve it further. Given that, it could make sense for me to supplement only DHT (topical) (without T) to upregulate 5AR, even if just for a few months.
As the upregulation change would be permanent, I could get over 1000 (DHT and T).
What dose would make sense to avoid suppressing endogenous DHT production too much (so I could recover relatively well)?
The drop in free t is normal when you drop carbs/calories. it'll go back up.
16mg of topical dht (say 5mg/3x per day) is virtually non-suppressive and increases free T and fertility markers
https://x.com/BowTiedUM/status/1878868128236736731
This isn't using the DMSO gel though, that would be suppressive
Do you have any experience with a Sperti Vitamin D panel? I live in a northern climate, and currently try to red light a couple times a week. I try to get outside as much as possible but given the short days it can be hard some days to get much sunlight.
It works great if combined with a red/ir panel
33-year-old male with strong non-lab markers (libido, energy, motivation, lean body composition, circadian rhythm). Dialed-in nutrition, regular resistance training, sprints, and grounding.
DHT: 31
Testosterone: 557
Free T: 124
FSH: 6.3
LH: 6.2
A1c: 5.1
LDL: 113
HS CRP: 0.5
Vitamin D: 75
Years of platelets trending low with MPV consistently high.
What strategies or tweaks could optimize hormonal balance and overall well-being further? Is it time for the DHT Stack?!
You probably want to get that LDL down as well. Probably have a slightly higher apo(B) based on that if i had to guess.
Will check for that, always had very low cholesterol markers, so wasn't very concerned to see this come up over the last couple years. Thanks
What is the implication of platelets trending low and MPV high, in your view?
Always thought autoimmunity, since runs strong in maternal line.
TPO antibodies used to be elevated years ago (with normal thyroid hormone markers), Hashimotos, signs of joint stuff in the past, but no change in platelets/MPV since all of that has improved.
Maybe time to revisit a more in depth thyroid panel.
We have very similar statistics, age, lifestyle brother!
Thanks for the reply. I ask because I actually have very similar bloods to you (including the trending low platelets and high MPV), but I'm also 11 years younger than you.
It makes sense that platelet turnover rate is higher, so newly produced platelets are younger and therefore larger, hence the increase in MPV as platelets stay down. I haven't checked bone marrow, but haven't come to a better understanding thus far. Any hunch on your end? I've been noticing it for probably 10 years.
I have no clue and didn't think anything of it until you noted observing the same trend above
Were you able to get TPO antibodies to 0?
I got them below 7, but haven't followed up in some time, might be interesting to recheck, as it's been some time.
Messaged you