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Idk if this is a biohacking Q or not but I cannot find a straight answer: what is the biological mechanism that will increase my endurance running speed, ie I run at a given pace for 30 min in zone 4 and I am wondering what in my body will adapt to that pace and require less strain to achieve the same pace and whether it is predictable and manipulatable by exogenous supplements

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There are so many!

Oxygen carrying capacity

Enhanced ATP production

Mitochondrial biogenesis

PPAR delta upregulation

Enhanced lipolysis/glucose retention

Enhanced nutrient uptake

Increased slow twitch muscle fiber

Angiogenesis

Lactate threshold improvement

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A lot of potential things to focus on and progress. Gracias fren

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