Did a WBC test and found that I have a bunch of deficiencies. Barely any copper, Vit A, Vit K, floor levels of cysteine, b12, b6, vit c, inositol, and a bunch of other shit. Very frustrating as it just points to me not eating the right foods and/or having absorption issues.
Also did a Mitome test and found my complex 1 is running at like 23 % basically impaired glucose metabolism and 80% complex 2 fat metabolism.
Where do I start with all this, do I fix the nutrient deficiencies and do things start to fall in place? And how heavily would you rely on supplements? Im trying to do 1-2oz liver a day now but its hard to get down. Thanks for what you do man. I was doing low dose andractim but think that the low androgens are prob related to all these deficiencies I found out about so switching focus a bit
Surprisingly I dont feel like shit everyday which makes me wonder
What is your opinion on low dose accutane (10-20mg)? Is there anything I should be cautious about? What is the cumulative dosage I should hit if you think it is okay and is fine to take it while on a future steroid cycle?
For context, I developed seborrheic dermatitis/bad dandruff after doing a steroid cycle which I believe grew my sebaceous glads/increased sebum production and want to take low dose accutane to shrink the glands/lower sebum production. My diet, circadian rhythm, etc. are locked in.
If you say so, but the seb derm has persisted ever since I did a steroid cycle which I believe was caused by androgens growing my sebaceous gland and has persisted since despite being natty. Just looking for your opinion on low dose accutane
A steroid cycle (no other context given) revealed underlying dysfunction and you want permission for accutane.
Seborrheic dermatitis specifically is a circadian condition
Malassezia colonization and the lipid metabolism of the sebaceous gland are both under clock gene regulation. If your exposure at night is disrupting BMAL1 cycling in sebocytes, you can have perfect "diet" have dysregulated gland output. Seb derm that "persists despite being natty" strongly suggests a circadian or mitochondrial driver, not a residual androgen one. Or maybe you just finished puberty, and again the underlying dysfunction was revealed. Congratulations if that is the case.
Retinol from beef liver (can use desiccated caps from ancestral supps) and cod liver oil does exactly what accutane does
Cod liver oil also provides EPA/DHA, which reduces omega 6 inflammatory lipids in sebum (we know your diet isn't perfect or you wouldn't possibly be asking)
UV and violet light potently kill Malassezia and C. acnes - this is why everyone should invest in radiance or trinity if theyre not able to sunmax all the time
300-600mg panthetine and 1000mg l carn 3x a day is also the literally accutane equivalent otc way to clear even severe cystic up right away while the underlying stuff is taken care of. Biotin with is a good idea.
Not to mention lactoferrin alone is good at clearing up cystic acne and sebboric dermatitis for several reasons
So all that is far superior to 10-20mg of accutane and isn't toxic. Yes we took low dose accutane in the past and regret it. We didnt realize there were better options. It destroyed opsins and caused tons of health issues years down the line.
You guys seriously can't keep doing the thing where you say "diet circadian etc is locked in please give me permission to take this thing" at least be genuine 😝
I am not understanding what you mean by "Congratulations if that is the case" and how an underlying dysfunction was revealed. I am not trying to ask for permission to take accutane. I am just trying to find a solution that is that does not require me using anti-dandruff product because I did not have to use them prior to that cycle. My cycle was 750mg test and 25mg anavar by the way. I currently get outside sun exposure during the morning, afternoon (uvb), night; I have iris on my computer, use incandescent lights, and so on. I also eat 2:1 omega 3 to omega 6 from salmon and other fish products and still have not seen improvement. I also have a sperti and use that. I have also tried vitamin b5 and l carntine as well and have not seen improvements. I am just trying to find a solution and it seems like accutane is one of my last options.
Thoughts on stage four Parkinson's? What can someone do at this point beyond regular exercise/muscle training, a good diet, etc? Assume that the standard meds are being taken for context. I'm not asking for medical advice nor will I interpret any answer as such.
If you're asking this question, sounds like you need to brush up on your biochem, molecular biology, drug delivery science and the meta skill (research lol) my brother!
Stomach acid + pepsin does hydrolyze most peptides into smaller fragments or aminos, but Khavinsons group repeatedly referred to bioregulators as "low hydrolysable" peptides and proved that in tact peptides reach target tissues with many animal and human studies.
There are dedicated transport proteins in the lower intestines for them (PEPT1 and PEPT2)
Pinealon being 3 aminos is the perfect substrate, but epitalon at 4 is close enough and this is proven in docking studies https://pmc.ncbi.nlm.nih.gov/articles/PMC9323678/ and the abundance of anecdotal reports
Smart formulations use enteric coated capsules so they don't even dissolve until they get to the location of pept1 and pept2
And what you said about the skin is incorrect btw
Skin is TERRIBLE for bioregulators and peptides without seriously intelligent delivery science
Theyre hydrophilic so they can't even cross the Stratum corneum and while they sit on the surface, they're destroyed by proteases and peptidases.
This is why we promote mirror skin, because theyre literally the ONLY company that's doing transdermal delivery right , and anyone who takes some time to research this stuff would realize that too, but no. They see other serums for a few bucks cheaper and think “ahh! Bowtied biohacker is just shilling for affiliate bucks” because they don't have the attention span. But lol, for what?? To take home ~$5 if someone uses the coupon code 😂
Nah, just trying to be nice and not call you a retard for associating mood, your penis, and lower glute pain with aspirin intake and then not even asking a coherent question 😂
I'm aware of the consequences of watching porn and busting from masturbation, and I do neither, but I'm curious - are there similar consequences associated with jerking it without porn (and not ejaculating) / edging to get bigger loads and increased blood flow down there? Does the stimulation impact dopamine or androgen receptors?
Any suggestions as to *who* to work with/where to look when dealing with persistent chronic kidney stones (otherwise perfect health)? Doctors largely ineffectual and everyone has different answers in terms of blood markers/regular to-dos. Starting to get a bit discouraged. Have passed over 50 in the last year.
50+ stones in a year puts you well past "stone prone" and into a metabolic stone phenotype that needs a dedicated stone program, not a general urologist. The reason everyone has given you different answers is that without two foundational pieces of data, any protocol is guessing.
1. Stone composition analysis
Catch one, send it to Louis C. Herring Laboratory or the Mayo Renal Testing Lab. Calcium oxalate monohydrate, calcium oxalate dihydrate, calcium phosphate, uric acid, struvite, and cystine all point to completely different root causes. Treating without this is a shot in the dark.
2. Litholink 24-hour urine panel, ideally two collections on typical days.
Ordered through LabCorp by any urologist or nephrologist. Measures urinary calcium, oxalate, citrate, uric acid, sodium, magnesium, volume, pH, and calculates supersaturation for the common stone types. This shows what's dysregulated in your chemistry, which standard bloodwork completely misses.
The program that consistently solves cases general urologists can't is the University of Chicago Kidney Stone Program under Fredric Coe and Elaine Worcester, who built the modern metabolic framework for stone disease and publish the entire clinical framework free at kidneystones.uchicago.edu. Read that site before your next appointment. The Mayo Clinic Hyperoxaluria Center becomes the right destination if primary hyperoxaluria ends up on the differential. Cleveland Clinic and UCSF also run dedicated stone metabolism endourology. General urologists handle stones mechanically with shockwave, ureteroscopy, and stents. A stone program treats the underlying chemistry.
Conditions to rule out before accepting "idiopathic"
Primary hyperparathyroidism. Serum calcium, ionized calcium, PTH, 25-OH D, 1,25-OH D, phosphorus. Gets missed constantly because PTH can sit in the high normal range with a normal serum calcium and still drive aggressive stone formation in an otherwise healthy patient.
Primary hyperoxaluria. Genetic testing for AGXT, GRHPR, HOGA1. Rare in general populations, but at your stone rate it has to be excluded.
Enteric hyperoxaluria from fat malabsorption and gut dysbiosis, especially with any significant prior antibiotic history that would have depleted Oxalobacter formigenes.
Cystinuria. Urine cystine screen.
RBC magnesium rather than serum magnesium, B6 (P5P) status, prior antibiotic exposure, fructose and sugar load, gut transit and fat digestion, and the 25-OH to 1,25-OH vitamin D ratio. Magnesium is a primary inhibitor of calcium oxalate nucleation in urine. B6 is the cofactor preventing endogenous oxalate synthesis from glyoxylate. A disrupted microbiome loses the species that degrade dietary oxalate before absorption. These layer on top of the metabolic workup once you know which stone type you're actually fighting.
Don't accept "drink more water and cut oxalate" as a treatment plan. At 50 stones a year something specific is broken, and it is almost always findable with the right workup.
Is PMSF still a viable way to expedite a cut phase if used strategically during it and not repeatedly every day?
Did a WBC test and found that I have a bunch of deficiencies. Barely any copper, Vit A, Vit K, floor levels of cysteine, b12, b6, vit c, inositol, and a bunch of other shit. Very frustrating as it just points to me not eating the right foods and/or having absorption issues.
Also did a Mitome test and found my complex 1 is running at like 23 % basically impaired glucose metabolism and 80% complex 2 fat metabolism.
Where do I start with all this, do I fix the nutrient deficiencies and do things start to fall in place? And how heavily would you rely on supplements? Im trying to do 1-2oz liver a day now but its hard to get down. Thanks for what you do man. I was doing low dose andractim but think that the low androgens are prob related to all these deficiencies I found out about so switching focus a bit
Surprisingly I dont feel like shit everyday which makes me wonder
What is your opinion on low dose accutane (10-20mg)? Is there anything I should be cautious about? What is the cumulative dosage I should hit if you think it is okay and is fine to take it while on a future steroid cycle?
For context, I developed seborrheic dermatitis/bad dandruff after doing a steroid cycle which I believe grew my sebaceous glads/increased sebum production and want to take low dose accutane to shrink the glands/lower sebum production. My diet, circadian rhythm, etc. are locked in.
"My diet, circadian rhythm, etc. Are locked in" evidently not at all or you wouldn't be considering Accutane 😂
If you say so, but the seb derm has persisted ever since I did a steroid cycle which I believe was caused by androgens growing my sebaceous gland and has persisted since despite being natty. Just looking for your opinion on low dose accutane
A steroid cycle (no other context given) revealed underlying dysfunction and you want permission for accutane.
Seborrheic dermatitis specifically is a circadian condition
Malassezia colonization and the lipid metabolism of the sebaceous gland are both under clock gene regulation. If your exposure at night is disrupting BMAL1 cycling in sebocytes, you can have perfect "diet" have dysregulated gland output. Seb derm that "persists despite being natty" strongly suggests a circadian or mitochondrial driver, not a residual androgen one. Or maybe you just finished puberty, and again the underlying dysfunction was revealed. Congratulations if that is the case.
Retinol from beef liver (can use desiccated caps from ancestral supps) and cod liver oil does exactly what accutane does
Cod liver oil also provides EPA/DHA, which reduces omega 6 inflammatory lipids in sebum (we know your diet isn't perfect or you wouldn't possibly be asking)
UV and violet light potently kill Malassezia and C. acnes - this is why everyone should invest in radiance or trinity if theyre not able to sunmax all the time
300-600mg panthetine and 1000mg l carn 3x a day is also the literally accutane equivalent otc way to clear even severe cystic up right away while the underlying stuff is taken care of. Biotin with is a good idea.
Not to mention lactoferrin alone is good at clearing up cystic acne and sebboric dermatitis for several reasons
So all that is far superior to 10-20mg of accutane and isn't toxic. Yes we took low dose accutane in the past and regret it. We didnt realize there were better options. It destroyed opsins and caused tons of health issues years down the line.
You guys seriously can't keep doing the thing where you say "diet circadian etc is locked in please give me permission to take this thing" at least be genuine 😝
I am not understanding what you mean by "Congratulations if that is the case" and how an underlying dysfunction was revealed. I am not trying to ask for permission to take accutane. I am just trying to find a solution that is that does not require me using anti-dandruff product because I did not have to use them prior to that cycle. My cycle was 750mg test and 25mg anavar by the way. I currently get outside sun exposure during the morning, afternoon (uvb), night; I have iris on my computer, use incandescent lights, and so on. I also eat 2:1 omega 3 to omega 6 from salmon and other fish products and still have not seen improvement. I also have a sperti and use that. I have also tried vitamin b5 and l carntine as well and have not seen improvements. I am just trying to find a solution and it seems like accutane is one of my last options.
Hi BTB! 167lbs/6ft. 16% bodyfat I’d say. Natural completely. 4 lifts per week, 8-10k steps/day.
Went on a 1900-2000cal cut. 2 weeks and already high cortisol, bad sleep, weak morning wood, face puffiness and constipation as well.
I don’t feel like this is the right thing to do so I am asking for your advice.
Macros were more or less 180/200/60 (prot/carbs/fat).
It would sound like your caloric deficit and macros has nothing to do with it, and you're instead just experiencing the effects of high stress
Thoughts on stage four Parkinson's? What can someone do at this point beyond regular exercise/muscle training, a good diet, etc? Assume that the standard meds are being taken for context. I'm not asking for medical advice nor will I interpret any answer as such.
How does oral Epitalon/Pinealon even work when the stomach acid literally breaks down them down into individual amino acids?
The skin does not have that mechanism which makes it plausible that bioregulators actually get to where they're needed to do the intended task.
If you're asking this question, sounds like you need to brush up on your biochem, molecular biology, drug delivery science and the meta skill (research lol) my brother!
Stomach acid + pepsin does hydrolyze most peptides into smaller fragments or aminos, but Khavinsons group repeatedly referred to bioregulators as "low hydrolysable" peptides and proved that in tact peptides reach target tissues with many animal and human studies.
There are dedicated transport proteins in the lower intestines for them (PEPT1 and PEPT2)
Pinealon being 3 aminos is the perfect substrate, but epitalon at 4 is close enough and this is proven in docking studies https://pmc.ncbi.nlm.nih.gov/articles/PMC9323678/ and the abundance of anecdotal reports
Smart formulations use enteric coated capsules so they don't even dissolve until they get to the location of pept1 and pept2
And what you said about the skin is incorrect btw
Skin is TERRIBLE for bioregulators and peptides without seriously intelligent delivery science
Theyre hydrophilic so they can't even cross the Stratum corneum and while they sit on the surface, they're destroyed by proteases and peptidases.
This is why we promote mirror skin, because theyre literally the ONLY company that's doing transdermal delivery right , and anyone who takes some time to research this stuff would realize that too, but no. They see other serums for a few bucks cheaper and think “ahh! Bowtied biohacker is just shilling for affiliate bucks” because they don't have the attention span. But lol, for what?? To take home ~$5 if someone uses the coupon code 😂
My bad! By skin I meant 💉, subcutaneous and/or intramuscular. My biochem does need brushing up tho.
Been taking baby aspirin for a week and feeling amazing. A bit more “on”, mood better, erections a lil better, flaccid hanging a lil lower
but body has been aching especially lower back/glutes.
Any way to combat this or will it go away? Or just not for me(please don’t say so lol) ?
Hi Rolo, without any other context we are completely stumped and not sure what any of those things have to do with each other!
VA AI ahh response lol 💚
Nah, just trying to be nice and not call you a retard for associating mood, your penis, and lower glute pain with aspirin intake and then not even asking a coherent question 😂
Lmaooooooo ok forget about this question but can always call me a retard btw because I am
I'm aware of the consequences of watching porn and busting from masturbation, and I do neither, but I'm curious - are there similar consequences associated with jerking it without porn (and not ejaculating) / edging to get bigger loads and increased blood flow down there? Does the stimulation impact dopamine or androgen receptors?
Not totally sure what to look for in a good red light device. I have heard you mention Chroma before, would you recommend their “Chromatorch product”?
https://getchroma.co/products/chromatorch
We have basically every chroma product but not that one. But now I want that and I'm gonna buy it so thank you 😂
Hahah that makes me feel better, going to make a purchase as well. Looks great for travel and post gym
Any suggestions as to *who* to work with/where to look when dealing with persistent chronic kidney stones (otherwise perfect health)? Doctors largely ineffectual and everyone has different answers in terms of blood markers/regular to-dos. Starting to get a bit discouraged. Have passed over 50 in the last year.
50+ stones in a year puts you well past "stone prone" and into a metabolic stone phenotype that needs a dedicated stone program, not a general urologist. The reason everyone has given you different answers is that without two foundational pieces of data, any protocol is guessing.
1. Stone composition analysis
Catch one, send it to Louis C. Herring Laboratory or the Mayo Renal Testing Lab. Calcium oxalate monohydrate, calcium oxalate dihydrate, calcium phosphate, uric acid, struvite, and cystine all point to completely different root causes. Treating without this is a shot in the dark.
2. Litholink 24-hour urine panel, ideally two collections on typical days.
Ordered through LabCorp by any urologist or nephrologist. Measures urinary calcium, oxalate, citrate, uric acid, sodium, magnesium, volume, pH, and calculates supersaturation for the common stone types. This shows what's dysregulated in your chemistry, which standard bloodwork completely misses.
The program that consistently solves cases general urologists can't is the University of Chicago Kidney Stone Program under Fredric Coe and Elaine Worcester, who built the modern metabolic framework for stone disease and publish the entire clinical framework free at kidneystones.uchicago.edu. Read that site before your next appointment. The Mayo Clinic Hyperoxaluria Center becomes the right destination if primary hyperoxaluria ends up on the differential. Cleveland Clinic and UCSF also run dedicated stone metabolism endourology. General urologists handle stones mechanically with shockwave, ureteroscopy, and stents. A stone program treats the underlying chemistry.
Conditions to rule out before accepting "idiopathic"
Primary hyperparathyroidism. Serum calcium, ionized calcium, PTH, 25-OH D, 1,25-OH D, phosphorus. Gets missed constantly because PTH can sit in the high normal range with a normal serum calcium and still drive aggressive stone formation in an otherwise healthy patient.
Distal renal tubular acidosis. Fasting urine pH, serum bicarbonate, anion gap.
Primary hyperoxaluria. Genetic testing for AGXT, GRHPR, HOGA1. Rare in general populations, but at your stone rate it has to be excluded.
Enteric hyperoxaluria from fat malabsorption and gut dysbiosis, especially with any significant prior antibiotic history that would have depleted Oxalobacter formigenes.
Cystinuria. Urine cystine screen.
RBC magnesium rather than serum magnesium, B6 (P5P) status, prior antibiotic exposure, fructose and sugar load, gut transit and fat digestion, and the 25-OH to 1,25-OH vitamin D ratio. Magnesium is a primary inhibitor of calcium oxalate nucleation in urine. B6 is the cofactor preventing endogenous oxalate synthesis from glyoxylate. A disrupted microbiome loses the species that degrade dietary oxalate before absorption. These layer on top of the metabolic workup once you know which stone type you're actually fighting.
Don't accept "drink more water and cut oxalate" as a treatment plan. At 50 stones a year something specific is broken, and it is almost always findable with the right workup.