50 Comments
User's avatar
Thomas's avatar

Is 30mg bromantane sublingual with cod liver oil + l tyrosine 700mg a day a good overall protocol? Saw some people say do 5 on 2 off cycling but wasn't sure what the proper cycle was.

BowTied Biohacker's avatar

Bromantane - 4-12 on 4-12 off works great for us. Doesn't have to be 1:1 in russia it's prescribed daily. Depends on needs at the time, how you feel, etc. breaks are good though

Bee's avatar
Feb 25Edited

Mother (60’s) had a relatively minor ischemic stroke. Also found a partially dissected artery, that is now healed, which they believe is unrelated to the stroke.

They put her on a statin, BP medication, and 325mg of aspirin per day.

What stack or protocol would you put her on?

Juan's avatar

I remember you talk about taking Agmatine when taking stimulants, as a neuroprotection. Do you take it aswell with coffee? Or you don't drink coffee. It's hard for me to quit coffee as I can feel instantly my dopamine rise

BowTied Biohacker's avatar

Yeah, it's great for neuroprotection with all stimulants, including caffeine

Juan's avatar

what dosage are we talking about?

shitface's avatar

How do you protect your energy when you're forced to interact with people who seem negative or draining especially when avoidance isn't an option, like dealing with a service worker / barista etc. I have noticed that people with heavy, negative energy seem particularly drawn to those who are spiritually positive, and the wife tends to bear the brunt of it. Are there any practical spiritual defense techniques for these situations?

BowTied Biohacker's avatar

The whole idea that someone can "drain your energy" is the belief that's doing the damage.

You cannot perceive what you are not the frequency of, so if that barista's bad vibes are landing on your wife, that's her higher mind showing her exactly where she's holding a belief about being vulnerable or responsible for other people's emotional states.

The "defense technique" is understanding that negative only has the power you give it, and the moment you stop buying into the idea that you need protection, you realize you never needed it.

Stay in your frequency, recognize what you don't prefer without judging it as bad, and that person's energy literally cannot touch you.

beepboop's avatar

Quick questions regarding an anabolic DHT protocol:

- What's a good ratio to E2 to start with?

- If using E2, is no T base needed at all? No matter how high the DHT dose?

- If doing 200mg DHT for example, anabolic-wise, what is approximately the T equivalent dose? 70mg? So anabolic wise, it's about a 3:1 ratio?

BowTied Biohacker's avatar

1. ~1mg E2 for every 200mg DHT

2. correct

3. What???DH T is 3x+ more anabolic than T. 200mg dht is like 600mg test if e2 is sufficient - honestly bro don't try this at home without medical supervision LOL!

beepboop's avatar

Oh ok, so it's the other way around lol.

I've been running 25mg solo for some time and looking to jump to 100mg. It's probably better to try 50mg with .25 E2 for a month to gauge response first, yeah?

For doing it without medical supervision, is running basic testing not enough? If not, can you release a guide on it maybe? lol. (You know, cause of the benefits it has over running T)

Rudra's avatar

If consuming 5mg/lb of body weight of magnesium (as per your recommendation) continues to give me loose stools even after months of adherement, would you recommend me to titrate down or continue until digestion issues stop?

In this case multi form saturation is being followed: Glycinate capsules, Acetyl Taurate powder, malate capsules, chloride in water, and topical chloride spray. All capsules are from Nootropics Depot or Double Tree.

I’ve tried abstaining from consuming Mag Cl in water but loose stools still persist.

Digestion otherwise is fine and everytime I’ve stopped supplement Mg, my loose stools have stopped.

Am I just incredibly deficient?

BowTied Biohacker's avatar

Titrate down to where your stools normalize and hammer the topical MgCl harder to make up the difference, because if your gut is still rebelling after months you're past bowel tolerance and just flushing money down the toilet (literally). Your body is telling you something, listen to it and let the skin absorb what the gut can't handle.

Rudra's avatar

Sounds good. Appreciate the reply UM 🙏

Irina katha's avatar

How to still increase penis size girth naturally with 23

years of age

Vladimir Mirakian's avatar

Hi UM! Is it true that low fat high carb diet is superior to low carb high fat? I read that low carb makes you low T low Thyroid and causes higher sympathetic tone aka fight or flight response.

Assume both diets have 1g of protein per pound of bodyweight.

BowTied Biohacker's avatar

Ah yes, that's a popularRay Peat community view. It's not even Ray Peat's view, though he was definitely wrong about a lot.

You need omega 3 fats, particularly DHA for your brain, eyes, everything. You need them to perceive reality properly. You need cholesterol to synthesize T and other hormones, so low fat is never really a good idea.

Carb tolerance is dictated by your light environment, so eat carbs seasonally when UV is present and pull them back in winter when your mitochondria can't handle the deuterium load. The low Free T low thyroid stuff from low carb is real but it's a symptom of doing it year round like a robot instead of cycling with the photoperiod like every human always had before the last century or so lmao.

Vladimir Mirakian's avatar

I am currently experimenting with dietary approaches because I need to cut from 15-16 to 11-12 % bodyfat. I feel horrible at 1700-1900 calories which is my bodyweight times 10. Bad sleep, bloating, constipation, no morning wood etc.

I was thinking maybe you have like an optimal split of fats/carbs to not feel like shit. Or is feeling like that a necessary part of a cut?

Ralph's avatar

Any advice or protocol for shoulder impingement? I have it in my right shoulder, for several weeks it hurt to reach for things or do any pressing. Its slightly better now and I can reach for stuff but pressing and any dips at all are a no go still.

Anthony's avatar

What would be your priority list in purchasing land for health, sovereignty, and pure joy?

BowTied Biohacker's avatar

Joy because real lasting joy comes from the inner work. the shadow work and learning how to transmute the negative into a positive. it depend on and it's not affected by external factors.

LD's avatar

Whats you opinion on Fadogia agrestris? I saw some studies reporting potential toxicity to testes but I doubt it was done on humans.

BowTied Biohacker's avatar

Fadogia is mid at best anyway. The study showed destruction of spermatic cells and seminiferous tubules at the 50 and 100 mg/kg doses, and extract administration significantly reduced alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase in liver and kidney with corresponding increases in serum, plus elevated serum malondialdehyde across all dose group.

Here's the logical transfer argument: testicular Leydig cells and Sertoli cells are highly conserved between rats and humans because reproductive biology is under extreme evolutionary pressure to stay consistent across mammals. The mechanism of damage here isn't some rat specific quirk. It's oxidative stress (elevated malondialdehyde proves lipid peroxidation is occurring), enzyme leakage from cellular membranes (meaning cells are literally rupturing), and protein depletion in testicular tissue. Those are universal mammalian damage pathways, not human specific ones. Your Leydig cells respond to oxidative insult the same way a rat's do because the steroidogenic machinery is biochemically identical.

The fact that it also hammered liver and kidney enzymes tells you this compound has systemic cytotoxicity, it's not selectively targeting testes, it's damaging cell membranes broadly.

Rolo's avatar

Sweet spot/max for dry fast + any tips? Only done water fasting

Silvio's avatar

Also interested in this or a longer article. It's the final boss.

Rolo's avatar

Lol fr. Longest dry fast I’ve done is sleeping and maybe a few more hours when I was young and regarded

MileyCrabz's avatar

Do the peptides in blends like Glow and Klow have reduced potency? Or reduced enough that they aren’t worth it?

Have seen people talk about the interaction with copper and methionine which reduces potency. But others say that you’ll generally finish a vial fast enough so the % of potency loss is minimal.

I’ve only ever gotten these peptides individually, but blends seem to be much cheaper and convenient.

BowTied Biohacker's avatar

Those concerns aren't actually valid, but those blends suck. The ratios are completely whack. you're either way overdosing ghk or way underdosing bpc and tb

MileyCrabz's avatar

Thanks for clearing that up for me. Yeah I always thought the GHK was really high in those blends. Huge plus if getting them individually and being able to control the dose of each peptide

Isaac's avatar

Regarding low dose DHT, would running enclomiphene along side it yield any benefit or would it cause problems?

BowTied Biohacker's avatar

You need to read the article if you're asking this question because it compares the benefits and downsides of both. Adding a SERM on top of low DHT is not only pointless, it will give you side effects and worse results

Isaac's avatar

I've read the article multiple times. I've even done a deep dive via chatgpt. When I was using GPT it was actually suggesting they could be potentially synergistic since enclomiphene primarily targets ERα in the brain to drive LH/FSH, while per the article DHT's Metabolite focuses on ERβ:

"DHT's metabolite 3β-androstanediol is a potent estrogen receptor beta (ERβ) agonist - as potent as estradiol at that receptor. This creates a natural SERM effect:

Stimulates LH and testosterone production at low doses

Supports fertility instead of suppressing it"

When I was asking chat gpt it mentioned:

"The biggest risk of using DHT (even at low doses) is that it eventually exerts negative feedback on the hypothalamus, lowering LH and the using enclomiphene would act as an "insurance policy" to prevent the HPTA shutdown that DHT might otherwise cause."

Can you key me in on how and why it would cause side effects and worse results?

I am genuinely trying to develop a deeper understanding of the pathways involved here, thanks for your help.

BowTied Biohacker's avatar

GPT is horrendously wrong. Both DHT and 3a-diol (and androsterone too) block estrogen receptor mediated transcription. It's already doing what enclo does, but providing anabolic effect and ERB agonism. It does not suppress LH, the article specifically mentions that. Combining them both eould be redundant/less gains at the very least because enclo would further reduce estrogen signaling and igf1.

Miro Henzel's avatar

How to biohack sexual health, but later in 40-50, how to prevent penile fibrosis, reverse Peyronies, do you have any experience with glycocalyx repair, what supplements?

BowTiedInjuryLawyer's avatar

I’d love a quick protocol for solid kidney health. Diet, exercise, supplements, peptides, etc. Also, things to avoid..

BowTied Biohacker's avatar

Blood glucose, blood pressure, and hydration in check DAILY is #1

No tolerance for NSAIDS besides emergencies, alcohol, and all the synthetic toxic stuff in diet/environment that's too long to list

Astragalus extract at 2-4g per day is a miracle and It's pulled me and tons of people out of CKD levels - can run a lot higher, even 20g per day if kidneys are really fucked

a gram of NAC or 2 daily also notably improves GFR and protects kidneys

Anything good for mitochondria like ubiquinol, sun, red light, and grounding (which you could do with grounding shoes when you go on walks because movement is CRITICAL for kidney health as the lymphatic system works side by side with kidneys for detox)

a cycle of Pielotax bioregulator and thymosin beta 4 could also be a game changer for repairing damage - same with SS31 peptide (going back to mitochondrial pathways) but it's brutally expensive to run clinical 50mg doses daily.