58 Comments
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Thomas's avatar

Are there any insulin concerns with small dose daily HGH ( 1-2 iu) use for general health/recovery? Will add Insulin and glucose levels already look good just curious if that dose would affect them in any major way. Have a good one.

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BowTied Biohacker's avatar

Before fasted cardio or before bed (assuming circadian eating windows are respected) is probably not gonna be an issue

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BowTiedShmedium's avatar

Generally no. HGH pre bed is ideal for avoiding insulin issues

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BowTied Biohacker's avatar

When you stop using minoxidil you will experience heavy shedding so consider that. It doesn't matter, up to you.

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Griffith's avatar

In the case of TauroMag, is it better to take all 3 capsules at once or split them throughout the day?

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Gram's avatar

Is the honeymoon phase on trt real? How would a person go about setting up his trt protocol to avoid it (in his hamster ofc, not asking for medical advice)

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Bigninja's avatar

Hey BTB, my dad is 179cm/105kg, probaby insulin resistant from childhood (lots of PUFA)

Doesn’t eat more than 2500 calories but stores lots of belly fat, despite being relatively lean in legs and arms

What is the reason of this type of fat storage

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Chastin Sikes's avatar

Should I use the “count thermic effect food” option on Cronometer?

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Nudge's avatar

How would you support (lifestyle, nutrition, supplement, etc.) an adult who is still heavily challenged by childhood trauma (sexual abuse)?

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Rob J's avatar

I have seen some websites (elite research for one) have topical BPC 157 creams. In theory, would this be good to add to the hair loss protocol?

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Brandon's avatar

What dosage of Andractim gel to put on each nipple daily to get rid of fibrous gyno?

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shitface's avatar

How long would it take to reset receptors if someone is on reta for 14-15 weeks? Would a 2-3 week totally off reset it ?

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BowTied Biohacker's avatar

It's not even out of your body after 2-3 weeks brother. Minimum 4-6 weeks after it's cleared

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shitface's avatar

Wow insane half life, thank you

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Silvio's avatar

What do you think of the claim we're physiologically limited to 2 pounds of fat loss per week, especially when you consider GLP agonists or things like DNP?

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BowTied Biohacker's avatar

Proven time and time again to be wrong

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Kyle's avatar

Any advice for potential early, non-fibrous gyno? I've heard Raloxifene from SC is good, or Tamoxifene or even Dermacrine(?). Could also be that my body is just storing those last few pounds a little strangely but I'd like to have a protocol in place in case I find out it's something hormonal.

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BowTied Biohacker's avatar

If it’s early, non-fibrous, and you're still in the “itchy/puffy” stage,Andractim would be the best case is the gold standard. raloxifene 60 mg daily can also work. Tamox works too but hits libido harder and isn’t as tissue-selective.

Dermacrine (7-oxo-DHEA topical) is more of a cortisol modulator. won’t touch glandular estrogenic tissue directly but might help if your issue is high aromatase from stress/adiposity.

Key move is getting labs first: total T, free T, sensitive E2, SHBG, prolactin, DHT. Then act. Don’t nuke E2 if it's not elevated. If it’s just weird fat storage, lean out and retest.

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Kyle's avatar

Thank you!

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Crypto's avatar

What is best way to get a compound that has crystallized in a vial back to uncrystalized state? Tried running under war, water to no avail.

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BowTied Biohacker's avatar

Put it on a hotplate at 60°C for a min or 2 or even a stove on the lowest possible setting if youre careful

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poopsie912's avatar

If I am going to run your hair regrowth protocol that you dropped yesterday (the most recent one), should I continue to use minoxidil twice daily?

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Aaron's avatar

What are your thoughts on BAM-15? Seems to be a lot of focus on mitochondrial health in this and the functional health space recently. What do you think about its MOA and it overall?

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BowTied Biohacker's avatar

BAM-15 looks like the first true successor to DNP (potent, orally active, and seemingly safer)

Fat loss in a pill? Sign me up! Right???

Not so fast!

BAM15 works by transporting protons across the inner mitochondrial membrane without using ATP synthase and collapses the gradient just enough to make the electron transport chain burn more fuel and waste the energy as heat.

In mice that translated into roughly 55 to 60 percent drops in LDL-like ApoB, twelve to fifteen percent weight loss and higher insulin sensitivity without any changes in food intake, lean mass or core body temperature.

The structure is sketchy with its two fluorophenyl rings. While covalently bound organofluorine is not the same as free fluoride ions,aromatic defluorination does happen in vivo, and ionic fluoride is known to concentrate in the pineal gland, cut melatonin output, and disturb UPEs / mitochondrial enzymes.

You don’t want weaker UPE if your goal is redox coherence. UPEs reflect structured mitochondrial ROS, which act like metabolic “pings” to sync DNA repair, enzyme timing, and circadian clocks.

Flattening that signal may reduce oxidative noise, but it also risks muting essential bioelectric communication, and even reducing your ability to perceive reality/lowering your consciousness (Mind/body/spirit coherence)

Until metabolic fate studies show otherwise you have to assume there's significant risk to adding that in.

Uncoupling makes sense only after obesity resists light, EMF, nutrition and sleep fixes (doubtful this is ever gonna be the case)

Also, for the lab rats still living under artificial light and not respecting their circadian clocks, this could be a disaster.

As always, fix light, sleep, cold exposure and add carnitine first before considering any hardcore metabolic torches.

For the clinically insane lab rats that don't heed good advice, they'll hopefully stick to no more than 15mg once daily with food, track resting heart rate, temp, ALT, AST, creatinine, lipids and thyroid every four weeks, and limit any run to eight weeks until human kinetics and long-term toxicity are published

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Aaron's avatar

Appreciate the break down. Interesting stuff

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LD's avatar

I know HCG helps with fertility on TRT when HPA is shut down but:

Does HCG monotherapy suppress the HPA/HPT axis to the extent, that natural baseline fertility will decrease over time on a long term protocol of around 750–1000 IU per week or it works differently?

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BowTiedShmedium's avatar

Why would you chose HCG mono over test lmao. Do you enjoy high e2?

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LD's avatar

Well 2 resons. Havent started yet though.

1. Saw Vigorous Steve recommend it for a few weeks before starting TRT.

2. BTB once said its 2nd best test booster after test.

And as I plan to start trying to conceive with my wife early 2026 I thought its not worth to shut down natural sperm production just so I can start trt 6 months earlier. Thats why I was thinking HCG mono for 6-7 months if that wont shut down FSH anyway as some sort of middle ground.

Will e2 really be that bad on HCG mono (250iu 3x week) with DIM + CDG.

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BowTied Biohacker's avatar

Favorite would be 6.25 to 12.5mg DHTE 3x per week with that 250iu hCG 3x otherwise you're probably gonna be too estrogenic. Yes hCG technically shuts you down because it's an LH agonist. No, not the same thing as recovering from AAS. What are your current levels? Critical context

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LD's avatar

Test - 800

LH - 3,67

Fsh - 2,55

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BowTied Biohacker's avatar

Ya, that wouldn't be wise at all to throw hCG in then. Youre not low T

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LD's avatar

Okay I wont do it then, I havent thought is that pro estrogenic even with cdg+DIM with possible AI on hand.

So I guess only as addition to TRT to sustain testicular function and size..

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