The Limitless Peptide: Everything You Need to Know About Semax

Semax is a peptide that stands out for improving cognitive function, focus, libido, and overall well-being. If you are new to peptides, keep reading as we dive into the science behind Semax, its powerful effects, and the existing research that supports its benefits.

Semax is a synthetic peptide derived from a naturally occurring hormone, adrenocorticotropic hormone or ACTH, that plays a critical role in regulating the adrenal glands and the release of cortisol. 

The initial purpose behind Semax was to address various neurological conditions, particularly those related to cognitive dysfunction and neurodegenerative disorders. Over time, it has gained traction for its cognitive-enhancing effects, sparking interest among entrepreneurs, executives, politicians,  athletes, and nootropic enthusiasts.

This peptide consists of the amino acid sequence: Met-Glu-His-Phe-Pro-Gly-Pro. Each of these amino acids plays a specific role in Semax's mechanisms and potential effects. Here's a rundown on how each of these amino acids helps Semax:

Met (methionine): In Semax, Met serves as the starting point of the peptide chain, helping its overall structure. 

Glu (Glutamic Acid): Glu helps Semax function by modulating neurotransmitter systems in the brain, enhancing cognitive functions.

His (Histidine): Like Met, His helps to contribute to the overall stability of the peptide structure, as well as its functioning role in regulating pH levels in the body.

Phe (Phenylalanine): In the context of Semax, phenylalanine may influence the production and release of neurotransmitters such as dopamine or norepinephrine.

Pro (Proline): Proline is known to be a unique amino acid in terms of its role in maintaining the structural integrity of proteins. So, in the context of Semax, proline helps to contribute to the peptide's stability and functionality.

Gly (Glycine): Glycine is a non-essential amino acid involved in the synthesis of important compounds, meaning it is part of the structure of Semax, contributing to the overall properties of the peptide. 

Proline (Pro): = The second occurrence of proline in the peptide sequence reinforces the stability of Semax's molecular structure.

You can read this study here to see how the structure of Semax helps combat brain diseases and improve cognitive function.

Semax's molecular structure is a key factor in its ability to interact with biological systems and apply its cognitive-enhancing effects. By targeting specific receptors and processes in the brain, Semax harmonizes neurotransmitter systems, promoting neuroprotection and enhancing cerebral blood flow, which are among the mechanisms underlying its cognitive-enhancing properties. This peptide has shown its role in preventing and treating pathologies of the central nervous system. 

Pharmacology / Effects

Semax acts primarily on the central nervous system, influencing various neurotransmitter systems. It interacts with ACTH (as we discussed above), playing a role in adjusting the release of neurotransmitters such as dopamine and serotonin.

Studies suggest Semax exhibits neuroprotective effects, supporting neuronal survival and preventing damage caused by oxidative stress. In short, this means it can enhance cognitive function, including memory and learning capabilities. 

Improves Memory and Attention

Scientific studies have yielded compelling evidence of Semax's positive impact on memory and attention even in challenging circumstances:

• It stimulates learning and memory formation in rodents and humans, improving memory consolidation and promoting learning abilities. A conclusion extracted from two different studies explores the cognitive effects of Semax in the rat hippocampus, stating that Semax "stimulates learning and memory formation" in both rodents and humans.

• It is successfully used in treatments of patients with different diseases of the central nervous system (CNS). The research findings by Ashmarin et al. highlight Semax's remarkable cognitive-enhancing properties. 

Semax Increases Learning Capacity.

• Brain-derived neurotrophic factor (BDNF) facilitates the growth, differentiation, and survival of neurons, as well as the generation and strengthening of synapses, making it essential for learning and memory. Semax increases BDNF production. 

• Specific study findings indicate that the cognitive effects exerted by Semax are associated with increased BDNF protein levels in this brain region (with Semax being administered intranasally at 50 and 250 micron/kg, and the increased BDNF levels were seen after 3 hours)

• Many other findings also support the benefits of Semax increasing learning capacity through increased BDNF production, with this study seeing significantly increased levels of BDNF after 90 minutes of Semax administration.

Semax is Neurorestorative and Neuroprotective

Neurorestoration refers to the process of repairing damaged neural tissue, whereas neuroprotective involves measures to keep the nervous system safe from damage. These dual properties make Semax a valuable compound for promoting brain health and mitigating the effects of neurodegenerative conditions and injuries. 

• Semax supports the health and function of the nervous system. 

• Semax possesses anti-inflammatory properties that can reduce neuroinflammation. By alleviating inflammation, Semax supports the brain's healing and regenerative processes. A study published in 2020 concluded that Semax suppressed inflammatory genes, which account for the neuroprotective action of Semax.

• Semax has antioxidative properties, which combat oxidative stress and free radical damage in the brain. Reducing oxidative stress aids in preventing neuronal damage and maintaining cognitive function.

• Semax modulates the body's stress response, reducing the adverse effects of chronic stress on the nervous system. A well-regulated stress response is essential for neuroprotection.

• By increasing blood flow to the brain, Semax supports the delivery of oxygen and nutrients, further protecting neurons and neural tissue and enhancing cerebral blood flow.

Selank and the melanocortin receptors

The melanocortin receptor system comprises five 7-transmembrane G-protein coupled receptors commonly denoted as MC1R, MC2R, MC3R, MC4R and MC5R. 

MC1R: Predominates in the periphery, especially in the skin

MC2R: Located in the adrenal gland

MC3R: Distributed in the brain and periphery

MC4R: Present in both the brain and periphery
 

MC5R: Distributed throughout the body

These receptors play pivotal roles in essential functions such as feeding behavior, energy homeostasis, stress response, UV radiation response, sexual function and behavior. 

Semax Increases Libido

Specifically looking at MC3R, this receptor is known to play a role in the regulation of libido, which refers to a person’s overall sexual drive or desire. In the context of sexual function, these receptors are involved in the modulation of various physiological processes related to reproductive behavior and sexual arousal. 

Semax activates of MC3R, setting in motion a cascade of events associated with MC3R activation, including ligand binding and intracellular signaling ultimately responsible for its powerful libido-boosting effect.  I can personally attest that very few other compounds boost libido this well, and that’s not even what sex is taken for.  It’s up there with the “sex peptide” PT-141.

The specific details of how MC3R modulates libido are still an active area of scientific research. It is important to note that multiple factors contribute to libido, as the melanocortin system is just one component of an intricate network that regulates sexual behavior in humans. 

Safety Data/Risks

While Semax has demonstrated a favorable safety profile in preclinical and early clinical studies, as with any substance, individual responses may vary, and potential side effects should be considered.

The human trials and anecdotal reports have reported that Semax is well tolerated by patients, with mild and transient side effects reported. These may include headaches, irritation at the injection site, and, in rare cases, allergic reactions. 

There is even instances of users injecting twentyfour times the normal dose of Semax and only experienced a slight headache.

Those interested in using Semax should consult a medical professional. Other medications being taken, as well as pre-existing health conditions, need to be taken into account in every Semax protocol.

Dosing & Protocols

A Semax dose is typically administered through a nasal spray or through injection.

Dosages can vary based on individual factors, including body weight, tolerance, and the desired effects.

The dosages can range from micrograms to milligrams. Users should start with lower doses and gradually titrate upwards while monitoring for any adverse effects. 

A comparative study has shown that Semax improves brain circulation, stimulates memory and attention, and increases resistance to hypoxia over 20-24 hours after nasal spray administration in doses 0.015-0.050 mg/kg. Again, this is dependent on the individual basis.  

The following sample cycle is not medical advice and should be viewed as educational content only. Do not take Semax without the supervision and prescription of a licensed physician. An example of a dosage breakdown would be as follows:

Semax (Nasal Spray) - 600-900 mcg twice daily and titrate up as required.

Semax (Injectable)- 500mcg daily and titrate up to 1,000mcg (once/twice daily)

NA Semax:  (Nasal Spray) 300-1200mcg twice daily and titrate up as required.

NA Semax:  (Injectable) 150-300 mcg once daily and titrate up as required.

NA Semax Amidate (Nasal Spray): 300-900mcg once daily and titrate up as required.

Time on: 4 weeks

Time off: 2-4 weeks

Protocols for Semax usage also depend on the specific goals of the user. Cognitive enhancement may involve different dosing schedules compared to therapeutic applications for neurodegenerative disorders. As research advances, refined dosing guidelines may emerge to optimize the benefits of Semax while minimizing potential risks.

Difference Between Semax, NA Semax, and Amidate

NA Semax (N-Acetyl Semax) is a modified form of Semax with an N-acetyl group added. The addition of the N-acetyl group can increase the peptide's stability and bioavailability. NA Semax is believed to retain the anxiolytic properties of Semax, while more readily crossing the blood-brain barrier for increased potency. NA Semax is my personal favorite.

NA Semax Amidate is another modified form of Semax, where an amide group is added to the C-terminus of the N-acetylated Semax. This modification is likely to further increase its stability and bioavailability. The amidation may enhance its pharmacokinetic properties, leading to stronger and longer-lasting effects compared to Semax and NA Semax. Users typically report only needing one to two sprays per day, with more causing potential side effects that may last the whole day.

Where to Buy Semax (For Research)

Limitless Life Nootropics is my go-to supplier for Semax Nasal Spray. Every batch is 3rd party HPLC tested to ensure purity, shipping is Amazon-tier fast, and their customer service is great. They are truly the best in the game. If you are interested in Semax for your research, you can use the links below and coupon code “BOWTIED” for 15% off.

Semax

https://www.limitlesslifenootropics.com/product/semax-10ml-nasal-spray-30mg/?ref=nwm2njl

N-Acetyl Semax:

https://limitlesslifenootropics.com/product/n-acetyl-semax-nasal-spray-10ml-30mg/?ref=nwm2njl

N- Acetyl Semax Amidate:

https://limitlesslifenootropics.com/product/n-acetyl-semax-amidate-10ml-spray-30mg/?ref=nwm2njl

Semax & Semax Amidate Combo Spray:

https://www.limitlesslifenootropics.com/product/n-acetyl-semax-amidate-30mg-n-acetyl-selank-amidate-30mg-blend/?ref=nwm2njl