If you took two identical twins, put them on the same mass gain protocol, and cjc/ipa was the only difference....you probably wouldn't be able to tell a difference lol
Hey. I asked you awhile back about some complex neurological issues.
Complex neurological issues, burning, tingling, hotness, flushed feeling, fullness, puffiness, heat sensitivity. No specialist can seem to figure it out
BowTied Biohacker
Liked by BowTied Biohacker
Ah that's actually simple, but it's not something a pill will fix.
Burning, tingles, hotness, flushed feeling, fullness, puffiness, and heat sensitivity are tied together through the activity of NMDA receptors, which when overactive can lead to excessive calcium entry into neurons, high cortisol, and poor lymphatic drainage.
This can all be triggered by several factors, including magnesium deficiency, other nutritional deficiencies, lack of daily exercise/movement, circadian dysregulation, nnEMF/blue light exposure, chronic stress, and sunlight deficiency.
You're looking at an entire lifestyle revamp.
Since then I’ve been triying to nail all these things, with a small improvement.
I also have C4/C5 high grade canal stenosis which both my Neurosurgeon and Neurologist are unsure if are contributing to symptoms but Neurosurgeon said I will need an operation eventually.
Question is
Do you think the Stenosis could be contributing to these symptoms?
This is probably a question that’s come up before but i can’t seem to trace back the answer.
I know finasteride is normally a no go but how about topical finasteride? My trichologist did dna research on me and stated that minoxidil is 92% effective and topical finasteride 99% effective on me so she suggests a custom solution for me to apply topically daily.
For context i’m 28 and want to have kids in about 3 years
Mono took us out for a month. Stuffs no joke. Dessicated thymus and ta1 would have been nice for sure. Yeah, always wanna spend as much time as possible in the sun.
Ik we only get one question so not expecting a reply, maybe some help from shmedium, but he’s also preparing for a Muay Thai fight camp currently. If he feels good enough can he still train? Docs acting like his spleen will explode if hr surpasses 100.
What is your targeted elemental magnesium per day and how would you slowly titrate this up over time while avoiding the nasty side effect of disaster pants?
Hypothetically - if a person reach let’s say 1200-1500 ng/dl via HCG mono vs. Test only - what will be the difference in muscle mass/ mood / health markers, maybe conversion to DHT etc. and so on?
(Obviously E2 management would be monitored in both cases, starting lean, lifestyle dialed in and all that stuff) - only variable would be hcg mono vs test only
The rules are 1 question per person and I already answered 3 for you
I'm answering this for the other readers, but don't do this again.
Isolated UV light is bad too- says it in the guide
Some tanning beds have some red diodes in them and combined with some sun and red light panels at home, you can probably make it a net positive during the low UVI months of the year
Supplements? You're getting into drug territory with a request like that. Increasing androgen:Estrogen ratio will reduce sensation and delay ejaculation. The more dht and less e2 yiu have, the longer you'll last. And pelvic floor strength. Can't really think of any supp that can replace these
I spent about 8 months of last year yo-yo dieting. I went back and forth between binges, going into extreme calorie deficits, and just generally not making much progress. I finally got down to 9% body fat after 5 months of strict dieting(confirmed by dexa). I was 144 lbs and had/have no muscle. I used 1mg reta/week for about 8 weeks to finish the cut. I then completely ruined the rebound, and put on 17 lbs of basically all fat in 6 weeks. Maybe a little muscle. I am now probably 17% bodyfat. I am on trt so need to get back to low bodyfat. Little worried for my health being in a deficit for another 4 months. Would you go right back into a slow and steady cut or would aggressive be better?
In your rapid fat loss guides, you talk about refeeds to avoid down regulation (beyond psychological benefits).
> Generally, it’s recommended to only burn 2 lbs of fat per week to avoid muscle loss and metabolic slowdown, but since we hacked our biochemistry with fasting, l-carnitine, and modified protein-sparing fasts, muscle loss was minimal and we haven’t yet downregulated our metabolism much if at all. However, it’s getting dangerously close.
Any more insight into when metabolism gets down regulated? And how do GLP-1 agonists factor into this? I imagine more and more people can go longer with harsher diets when on sema/reta. But maybe they stave off down regulation?
Depends how fat and insulin/leptin resistant you are. But lets assume youre being smart and not getting fatter than 13-15%: metabolic downregulation usually begins after ~2–3 weeks of aggressive fat loss, especially once leptin, thyroid (T3), and sympathetic tone start to drop. Refeeds can temporarily restore leptin and give the CNS “permission” to keep burning. GLP-1 agonists like sema/reta blunt hunger and reduce sympathetic drive, which can mask signs of slowdown, but they don’t prevent it. You'll be in for a rude awakening kn the rebound. Muscle-sparing strategies + strategic refeeds are still key if you're pushing beyond that 3-week mark.
What’s the best protocol for getting rid of mild hyperpigmentation from acne on the chest? Success in eliminating the acne now just wanna continue to address a little hyperpigmentation.
The sunrise/set is the best pure red/ir light therapy that no panel can come close to - get an hour daily with chest exposed. Exfoliate. . You can use an panel as well to support additional collagen turnover, DNA repair, melanocyte distribution, mitoheaking, etc. Hit some nr/nmn/tmg supps with some mirror skin and maybe Niacinamide. + time
How long to correct omega 3 to omega 6 deficiency and are sardines in olive oil a good source to correct deficiency despite olive oil containing omega 6's or is the omega 6 negligible when it's drained?
What up Bio - any recommendations for a root canal and shingles recovery protocol? Tooth issues likely induced shingles. Had to run two rounds of antibiotics unfortunately as well.
I have been struggling with internal bleeding hemorrhoids that have caused extreme anemia. I've had 2 embolizations that seem to have been unsuccessful for the most part. I just started injecting BPC+TB500 (BPC 2x/day & TB 2x/wk) as a hail mary before reluctantly agreeing to invasive surgery. Is there any hope that this'll work? Do I need to tweek this protocol? Any insight would be appreciated. Its been a long road and I'm ready to finish the walk. 44yo, male, 5'11, 220. 34" waist. Work out 3-5 days a week. On TRT
Peptides can accelerate healing of the mucosa, but they cannot mechanically eliminate large, chronically prolapsed hemorrhoidal cushions. Not medical advice but If bleeding is still driving anemia, get an immediate CBC + ferritin and replenish iron (or transfuse) if Hgb < 8 g/dL or you're light-headed. In parallel, soften stool daily (30 g fiber, 2-3 L water, magnesium, squatty potty lol) and ask IR whether a feeder vein was missed. sometimes a quick repeat embolization or rubberband ligation saves you a full hemorrhoidectomy. Layer in proven venotonics-diosmin/hesperidin 1,000 mg/100 mg AM and butcher's broom 150 mg BID-because RCTs show they curb bleeding within 10 days. Rebuild tissue with collagen + vit-C each meal, copper 2-5 mg, K2-MK-7 100-200 μg, and keep ferritin > 100 ng/mL. Light + circadian hacks. Reevaluate 4 weeks later? Idk bro best wishes
This is more info and direction than I've been given in almost 2yrs navigating conventional healthcare. I appreciate it more than you know, bro. I really do. Thank you
Wen UMgpt?
This is doable with current substacks + tweets out tbh
Is Ipamorelin/CJC-1295 a good peptide for muscle gain?
If you took two identical twins, put them on the same mass gain protocol, and cjc/ipa was the only difference....you probably wouldn't be able to tell a difference lol
Thanks. Saved me some money there.
How about HCG?
Hey. I asked you awhile back about some complex neurological issues.
Complex neurological issues, burning, tingling, hotness, flushed feeling, fullness, puffiness, heat sensitivity. No specialist can seem to figure it out
BowTied Biohacker
Liked by BowTied Biohacker
Ah that's actually simple, but it's not something a pill will fix.
Burning, tingles, hotness, flushed feeling, fullness, puffiness, and heat sensitivity are tied together through the activity of NMDA receptors, which when overactive can lead to excessive calcium entry into neurons, high cortisol, and poor lymphatic drainage.
This can all be triggered by several factors, including magnesium deficiency, other nutritional deficiencies, lack of daily exercise/movement, circadian dysregulation, nnEMF/blue light exposure, chronic stress, and sunlight deficiency.
You're looking at an entire lifestyle revamp.
Since then I’ve been triying to nail all these things, with a small improvement.
I also have C4/C5 high grade canal stenosis which both my Neurosurgeon and Neurologist are unsure if are contributing to symptoms but Neurosurgeon said I will need an operation eventually.
Question is
Do you think the Stenosis could be contributing to these symptoms?
Thanks heaps sorry for the long story 👍🏻
Yeah it could. But I'd be suspicious of the neurosurgeon insistence on surgery. Maybe join Jack kruse's membership program and ask him what he thinks
Awesome. I’ll suss him out. Where do I find Jack Kruse’s membership?
Thanks heaps
This is probably a question that’s come up before but i can’t seem to trace back the answer.
I know finasteride is normally a no go but how about topical finasteride? My trichologist did dna research on me and stated that minoxidil is 92% effective and topical finasteride 99% effective on me so she suggests a custom solution for me to apply topically daily.
For context i’m 28 and want to have kids in about 3 years
Son has mono, sunlight and ta1 the ultimate get rid of that shit stack?
Mono took us out for a month. Stuffs no joke. Dessicated thymus and ta1 would have been nice for sure. Yeah, always wanna spend as much time as possible in the sun.
Ik we only get one question so not expecting a reply, maybe some help from shmedium, but he’s also preparing for a Muay Thai fight camp currently. If he feels good enough can he still train? Docs acting like his spleen will explode if hr surpasses 100.
What is your targeted elemental magnesium per day and how would you slowly titrate this up over time while avoiding the nasty side effect of disaster pants?
Hypothetically - if a person reach let’s say 1200-1500 ng/dl via HCG mono vs. Test only - what will be the difference in muscle mass/ mood / health markers, maybe conversion to DHT etc. and so on?
(Obviously E2 management would be monitored in both cases, starting lean, lifestyle dialed in and all that stuff) - only variable would be hcg mono vs test only
Youre PROBABLY not gonna get T that high from hCG without excess aromatization
I ll be on sufficient amounts od cdg + DIM with aromasin ready on hand to deploy immediately if needed.
Natty level is 830. So still unlikely to go to lets say 1200 with 750-1000/week?
Another one, related to your light environment guide:
How do tanning beds factor into the moral panic around UV/dermatologists?
I've never used one, but I'm wondering if there's more to it than just "they're cancer machines".
Might then even be beneficial?
The rules are 1 question per person and I already answered 3 for you
I'm answering this for the other readers, but don't do this again.
Isolated UV light is bad too- says it in the guide
Some tanning beds have some red diodes in them and combined with some sun and red light panels at home, you can probably make it a net positive during the low UVI months of the year
Thanks for answering, will stick to the rules. Though I only asked two, not three. Down regulation and this one.
Youve mentioned the following lifestyle changes to increase DHT.
Other than the things mentioned on your DHT post, what other lifestyle changes if any have you found to increase DHT Naturally WADA approved?
No fap and no nut otherwise start over (non negotiable)
- 5x5 Style lifting 4-6 times per week (sets of 3 and 1 included)
- 20 minutes of dedicated mindful breathwork daily
- 5 Mins of HIIT daily (more if able)
- 1-2x week sparring
That right there is the best way to go about it
What supplements would be most effective for delaying ejaculation and which pathways do they work on?
Supplements? You're getting into drug territory with a request like that. Increasing androgen:Estrogen ratio will reduce sensation and delay ejaculation. The more dht and less e2 yiu have, the longer you'll last. And pelvic floor strength. Can't really think of any supp that can replace these
Cialis 5-10mg and it’s not even close
I spent about 8 months of last year yo-yo dieting. I went back and forth between binges, going into extreme calorie deficits, and just generally not making much progress. I finally got down to 9% body fat after 5 months of strict dieting(confirmed by dexa). I was 144 lbs and had/have no muscle. I used 1mg reta/week for about 8 weeks to finish the cut. I then completely ruined the rebound, and put on 17 lbs of basically all fat in 6 weeks. Maybe a little muscle. I am now probably 17% bodyfat. I am on trt so need to get back to low bodyfat. Little worried for my health being in a deficit for another 4 months. Would you go right back into a slow and steady cut or would aggressive be better?
Tons of useful info in your guides.
In your rapid fat loss guides, you talk about refeeds to avoid down regulation (beyond psychological benefits).
> Generally, it’s recommended to only burn 2 lbs of fat per week to avoid muscle loss and metabolic slowdown, but since we hacked our biochemistry with fasting, l-carnitine, and modified protein-sparing fasts, muscle loss was minimal and we haven’t yet downregulated our metabolism much if at all. However, it’s getting dangerously close.
Any more insight into when metabolism gets down regulated? And how do GLP-1 agonists factor into this? I imagine more and more people can go longer with harsher diets when on sema/reta. But maybe they stave off down regulation?
Depends how fat and insulin/leptin resistant you are. But lets assume youre being smart and not getting fatter than 13-15%: metabolic downregulation usually begins after ~2–3 weeks of aggressive fat loss, especially once leptin, thyroid (T3), and sympathetic tone start to drop. Refeeds can temporarily restore leptin and give the CNS “permission” to keep burning. GLP-1 agonists like sema/reta blunt hunger and reduce sympathetic drive, which can mask signs of slowdown, but they don’t prevent it. You'll be in for a rude awakening kn the rebound. Muscle-sparing strategies + strategic refeeds are still key if you're pushing beyond that 3-week mark.
What’s the best protocol for getting rid of mild hyperpigmentation from acne on the chest? Success in eliminating the acne now just wanna continue to address a little hyperpigmentation.
Thanks!
The sunrise/set is the best pure red/ir light therapy that no panel can come close to - get an hour daily with chest exposed. Exfoliate. . You can use an panel as well to support additional collagen turnover, DNA repair, melanocyte distribution, mitoheaking, etc. Hit some nr/nmn/tmg supps with some mirror skin and maybe Niacinamide. + time
How long to correct omega 3 to omega 6 deficiency and are sardines in olive oil a good source to correct deficiency despite olive oil containing omega 6's or is the omega 6 negligible when it's drained?
Yeah the olive oil is not a problem. Give it 3 months
What up Bio - any recommendations for a root canal and shingles recovery protocol? Tooth issues likely induced shingles. Had to run two rounds of antibiotics unfortunately as well.
Currently have -
3IU GH
Lysine
Zinc
ND B Complex
Red Light (Inferno)
Grim BSO
Oral BPC
40g collagen daily
Planning to add BPC & TB next week too.
Where's the probiotics? Next week? Aren't you gonna be better by then?
Haha you’re right - any suggestion on probiotic? I have kefir going everyday. Thanks dude
Kefir
I have been struggling with internal bleeding hemorrhoids that have caused extreme anemia. I've had 2 embolizations that seem to have been unsuccessful for the most part. I just started injecting BPC+TB500 (BPC 2x/day & TB 2x/wk) as a hail mary before reluctantly agreeing to invasive surgery. Is there any hope that this'll work? Do I need to tweek this protocol? Any insight would be appreciated. Its been a long road and I'm ready to finish the walk. 44yo, male, 5'11, 220. 34" waist. Work out 3-5 days a week. On TRT
Peptides can accelerate healing of the mucosa, but they cannot mechanically eliminate large, chronically prolapsed hemorrhoidal cushions. Not medical advice but If bleeding is still driving anemia, get an immediate CBC + ferritin and replenish iron (or transfuse) if Hgb < 8 g/dL or you're light-headed. In parallel, soften stool daily (30 g fiber, 2-3 L water, magnesium, squatty potty lol) and ask IR whether a feeder vein was missed. sometimes a quick repeat embolization or rubberband ligation saves you a full hemorrhoidectomy. Layer in proven venotonics-diosmin/hesperidin 1,000 mg/100 mg AM and butcher's broom 150 mg BID-because RCTs show they curb bleeding within 10 days. Rebuild tissue with collagen + vit-C each meal, copper 2-5 mg, K2-MK-7 100-200 μg, and keep ferritin > 100 ng/mL. Light + circadian hacks. Reevaluate 4 weeks later? Idk bro best wishes
This is more info and direction than I've been given in almost 2yrs navigating conventional healthcare. I appreciate it more than you know, bro. I really do. Thank you